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COVID-19 rebound after Paxlovid treatment

Published May 24, 2022.

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  • Be aware, Centers for Disease Control and Prevention (CDC) issued a health advisory about COVID-19 rebound after Paxlovid treatment. Continue to offer Paxlovid for early-stage treatment of mild to moderate COVID-19 in people at high risk of severe disease.
  • Be aware, providers have reported COVID-19 rebound—recurring symptoms or a new positive test after a negative test—2–8 days after initial recovery. A brief return of symptoms may be part of SARS-CoV-2 infection in some people, regardless of treatment or vaccination status. Case reports suggest patients with COVID-19 rebound who were treated with Paxlovid have mild illness.

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