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Yes, the flu vaccination is very safe. CDC and the Food and Drug Administration (FDA) hold vaccines to the highest safety standards. Flu vaccines have been given to hundreds of millions of people and have been made the same way for decades. As with all vaccines, flu vaccine testing and safety monitoring are done in multiple phases. For vaccines to be approved, the manufacturing facilities and processes must meet standards to make sure that the vaccines are pure and effective. After vaccines are approved, each batch is tested before it is released to check purity and strength. Several systems are in place to watch for possible side effects after vaccines are given.